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10.1126/science.aai9127 http://scihub22266oqcxt.onion/10.1126/science.aai9127 C5351859!5351859 !27934701     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27934701 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Science 2016 ; 354 (6318 ): 1437-1440 Nephropedia Template TP {{tp|p=27934701 |t=2016. Translational termination without a stop codon |pdf=|usr=}}{{27934701 }} gab.com Text Translational termination without a stop codon JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=27934701 #FOAvip Ribosomes stall when they encounter the end of messenger RNA (mRNA) without an in-frame stop codon. In bacteria, these "nonstop" complexes can be rescued by alternative ribosome-rescue factor A (ArfA). We used electron cryomicroscopy to determine structures of ArfA bound to the ribosome with 3'-truncated mRNA, at resolutions ranging from 3.0 to 3.4 angstroms. ArfA binds within the ribosomal mRNA channel and substitutes for the absent stop codon in the A site by specifically recruiting release factor 2 (RF2), initially in a compact preaccommodated state. A similar conformation of RF2 may occur on stop codons, suggesting a general mechanism for release-factor-mediated translational termination in which a conformational switch leads to peptide release only when the appropriate signal is present in the A site. Twit Text FOAVip Translational termination without a stop codon ????Science http://www.kidney.de/pget.php?&tw=1&pmid=27934701 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27934701 #FOAvip English Wikipedia <ref>{{Cite pmid|27934701 }}</ref> Translational termination without a stop codon #MMPMID27934701 James NR ; Brown A ; Gordiyenko Y ; Ramakrishnan V Science 2016[Dec]; 354 (6318 ): 1437-1440 PMID27934701 show ga Ribosomes stall when they encounter the end of messenger RNA (mRNA) without an in-frame stop codon. In bacteria, these "nonstop" complexes can be rescued by alternative ribosome-rescue factor A (ArfA). We used electron cryomicroscopy to determine structures of ArfA bound to the ribosome with 3'-truncated mRNA, at resolutions ranging from 3.0 to 3.4 angstroms. ArfA binds within the ribosomal mRNA channel and substitutes for the absent stop codon in the A site by specifically recruiting release factor 2 (RF2), initially in a compact preaccommodated state. A similar conformation of RF2 may occur on stop codons, suggesting a general mechanism for release-factor-mediated translational termination in which a conformational switch leads to peptide release only when the appropriate signal is present in the A site. |*Codon, Terminator [MESH] |*Peptide Chain Termination, Translational [MESH] |3' Untranslated Regions [MESH] |Cryoelectron Microscopy [MESH] |Escherichia coli Proteins/chemistry/metabolism/*ultrastructure [MESH] |Escherichia coli/genetics/*metabolism [MESH] |Peptide Termination Factors/*chemistry/metabolism [MESH] |Peptides/chemistry/metabolism [MESH] |Protein Conformation [MESH] |Protein Stability [MESH] |RNA, Bacterial/chemistry [MESH] |RNA, Ribosomal/chemistry/metabolism [MESH] |RNA-Binding Proteins/chemistry/metabolism/*ultrastructure [MESH]Translational termination without a stop codon (epmc).pdf DeepDyve Pubget Overpricing