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2016 ; 594
(14
): 3877-909
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Translational neurocardiology: preclinical models and cardioneural integrative
aspects
#MMPMID27098459
Ardell JL
; Andresen MC
; Armour JA
; Billman GE
; Chen PS
; Foreman RD
; Herring N
; O'Leary DS
; Sabbah HN
; Schultz HD
; Sunagawa K
; Zucker IH
J Physiol
2016[Jul]; 594
(14
): 3877-909
PMID27098459
show ga
Neuronal elements distributed throughout the cardiac nervous system, from the
level of the insular cortex to the intrinsic cardiac nervous system, are in
constant communication with one another to ensure that cardiac output matches the
dynamic process of regional blood flow demand. Neural elements in their various
'levels' become differentially recruited in the transduction of sensory inputs
arising from the heart, major vessels, other visceral organs and somatic
structures to optimize neuronal coordination of regional cardiac function. This
White Paper will review the relevant aspects of the structural and functional
organization for autonomic control of the heart in normal conditions, how these
systems remodel/adapt during cardiac disease, and finally how such knowledge can
be leveraged in the evolving realm of autonomic regulation therapy for cardiac
therapeutics.