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2015 ; 7
(8
): 4326-51
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gab.com Text
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English Wikipedia
Translational Control of the HIV Unspliced Genomic RNA
#MMPMID26247956
Rojas-Araya B
; Ohlmann T
; Soto-Rifo R
Viruses
2015[Aug]; 7
(8
): 4326-51
PMID26247956
show ga
Post-transcriptional control in both HIV-1 and HIV-2 is a highly regulated
process that commences in the nucleus of the host infected cell and finishes by
the expression of viral proteins in the cytoplasm. Expression of the unspliced
genomic RNA is particularly controlled at the level of RNA splicing, export, and
translation. It appears increasingly obvious that all these steps are
interconnected and they result in the building of a viral ribonucleoprotein
complex (RNP) that must be efficiently translated in the cytosolic compartment.
This review summarizes our knowledge about the genesis, localization, and
expression of this viral RNP.