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2016 ; 38
(3
): 309-19
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Transient Receptor Potential (TRP) channels in T cells
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Bertin S
; Raz E
Semin Immunopathol
2016[May]; 38
(3
): 309-19
PMID26468011
show ga
The transient receptor potential (TRP) family of ion channels is widely expressed
in many cell types and plays various physiological roles. Growing evidence
suggests that certain TRP channels are functionally expressed in the immune
system. Indeed, an increasing number of reports have demonstrated the functional
expression of several TRP channels in innate and adaptive immune cells and have
highlighted their critical role in the activation and function of these cells.
However, very few reviews have been entirely dedicated to this subject. Here, we
will summarize the recent findings with regards to TRP channel expression in T
cells and discuss their emerging role as regulators of T cell activation and
functions. Moreover, these studies suggest that beyond their pharmaceutical
interest in pain management, certain TRP channels may represent potential novel
therapeutic targets for various immune-related diseases.