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10.1152/physrev.00019.2013

http://scihub22266oqcxt.onion/10.1152/physrev.00019.2013
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suck abstract from ncbi


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pmid24692352
      Physiol+Rev 2014 ; 94 (2 ): 383-417
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  • Transglutaminase regulation of cell function #MMPMID24692352
  • Eckert RL ; Kaartinen MT ; Nurminskaya M ; Belkin AM ; Colak G ; Johnson GV ; Mehta K
  • Physiol Rev 2014[Apr]; 94 (2 ): 383-417 PMID24692352 show ga
  • Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding functions that participate in regulation of cell fate in a wide range of cellular systems and are implicated to have roles in development of disease. This review highlights the mechanism of action of these proteins with respect to their structure, impact on cell differentiation and survival, role in cancer development and progression, and function in signal transduction. We also discuss the mechanisms whereby TG level is controlled and how TGs control downstream targets. The studies described herein begin to clarify the physiological roles of TGs in both normal biology and disease states.
  • |*Signal Transduction [MESH]
  • |Animals [MESH]
  • |Cell Differentiation [MESH]
  • |Gene Expression Regulation, Enzymologic [MESH]
  • |Humans [MESH]
  • |Neoplasms/enzymology/pathology [MESH]
  • |Transcription, Genetic [MESH]


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