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10.1016/B978-0-12-801105-8.00009-6

http://scihub22266oqcxt.onion/10.1016/B978-0-12-801105-8.00009-6
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suck abstract from ncbi


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pmid25172477
      Int+Rev+Neurobiol 2014 ; 116 (ä): 233-50
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  • Transcriptomic changes in brain development #MMPMID25172477
  • Dillman AA ; Cookson MR
  • Int Rev Neurobiol 2014[]; 116 (ä): 233-50 PMID25172477 show ga
  • The transcriptome changes hugely during development of the brain. Whole genes, alternate exons, and single base pair changes related to RNA editing all show differences between embryonic and mature brain. Collectively, these changes control proteomic diversity as the brain develops. Additionally, there are many changes in noncoding RNAs (miRNA and lncRNA) that interact with mRNA to influence the overall transcriptional landscape. Here, we will discuss what is known about such changes in brain development, particularly focusing on high-throughput approaches and how those can be used to infer mechanisms by which gene expression is controlled in the brain as it matures.
  • |Animals [MESH]
  • |Base Sequence [MESH]
  • |Brain/*growth & development/*metabolism [MESH]
  • |Gene Expression Regulation, Developmental/*physiology [MESH]
  • |Gene Expression/physiology [MESH]
  • |Humans [MESH]
  • |RNA Splicing [MESH]


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