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2014 ; 116
(ä): 233-50
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Transcriptomic changes in brain development
#MMPMID25172477
Dillman AA
; Cookson MR
Int Rev Neurobiol
2014[]; 116
(ä): 233-50
PMID25172477
show ga
The transcriptome changes hugely during development of the brain. Whole genes,
alternate exons, and single base pair changes related to RNA editing all show
differences between embryonic and mature brain. Collectively, these changes
control proteomic diversity as the brain develops. Additionally, there are many
changes in noncoding RNAs (miRNA and lncRNA) that interact with mRNA to influence
the overall transcriptional landscape. Here, we will discuss what is known about
such changes in brain development, particularly focusing on high-throughput
approaches and how those can be used to infer mechanisms by which gene expression
is controlled in the brain as it matures.