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Transcriptional regulatory networks for CD4 T cell differentiation
#MMPMID24839135
Christie D
; Zhu J
Curr Top Microbiol Immunol
2014[]; 381
(?): 125-72
PMID24839135
show ga
CD4(+) T cells play a central role in controlling the adaptive immune response by
secreting cytokines to activate target cells. Naïve CD4(+) T cells differentiate
into at least four subsets, Th1Th1 , Th2Th2 , Th17Th17 , and inducible regulatory
T cellsregulatory T cells , each with unique functions for pathogen elimination.
The differentiation of these subsets is induced in response to cytokine
stimulation, which is translated into Stat activation, followed by induction of
master regulator transcription factorstranscription factors . In addition to
these factors, multiple other transcription factors, both subset specific and
shared, are also involved in promoting subset differentiation. This review will
focus on the network of transcription factors that control CD4(+) T cell
differentiation.