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2015 ; 3
(ä): 66
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Transcriptional regulators of Na,K-ATPase subunits
#MMPMID26579519
Li Z
; Langhans SA
Front Cell Dev Biol
2015[]; 3
(ä): 66
PMID26579519
show ga
The Na,K-ATPase classically serves as an ion pump creating an electrochemical
gradient across the plasma membrane that is essential for transepithelial
transport, nutrient uptake and membrane potential. In addition, Na,K-ATPase also
functions as a receptor, a signal transducer and a cell adhesion molecule. With
such diverse roles, it is understandable that the Na,K-ATPase subunits, the
catalytic ?-subunit, the ?-subunit and the FXYD proteins, are controlled
extensively during development and to accommodate physiological needs. The
spatial and temporal expression of Na,K-ATPase is partially regulated at the
transcriptional level. Numerous transcription factors, hormones, growth factors,
lipids, and extracellular stimuli modulate the transcription of the Na,K-ATPase
subunits. Moreover, epigenetic mechanisms also contribute to the regulation of
Na,K-ATPase expression. With the ever growing knowledge about diseases associated
with the malfunction of Na,K-ATPase, this review aims at summarizing the
best-characterized transcription regulators that modulate Na,K-ATPase subunit
levels. As abnormal expression of Na,K-ATPase subunits has been observed in many
carcinoma, we will also discuss transcription factors that are associated with
epithelial-mesenchymal transition, a crucial step in the progression of many
tumors to malignant disease.