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10.3389/fcell.2015.00066

http://scihub22266oqcxt.onion/10.3389/fcell.2015.00066
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suck abstract from ncbi


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pmid26579519
      Front+Cell+Dev+Biol 2015 ; 3 (ä): 66
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  • Transcriptional regulators of Na,K-ATPase subunits #MMPMID26579519
  • Li Z ; Langhans SA
  • Front Cell Dev Biol 2015[]; 3 (ä): 66 PMID26579519 show ga
  • The Na,K-ATPase classically serves as an ion pump creating an electrochemical gradient across the plasma membrane that is essential for transepithelial transport, nutrient uptake and membrane potential. In addition, Na,K-ATPase also functions as a receptor, a signal transducer and a cell adhesion molecule. With such diverse roles, it is understandable that the Na,K-ATPase subunits, the catalytic ?-subunit, the ?-subunit and the FXYD proteins, are controlled extensively during development and to accommodate physiological needs. The spatial and temporal expression of Na,K-ATPase is partially regulated at the transcriptional level. Numerous transcription factors, hormones, growth factors, lipids, and extracellular stimuli modulate the transcription of the Na,K-ATPase subunits. Moreover, epigenetic mechanisms also contribute to the regulation of Na,K-ATPase expression. With the ever growing knowledge about diseases associated with the malfunction of Na,K-ATPase, this review aims at summarizing the best-characterized transcription regulators that modulate Na,K-ATPase subunit levels. As abnormal expression of Na,K-ATPase subunits has been observed in many carcinoma, we will also discuss transcription factors that are associated with epithelial-mesenchymal transition, a crucial step in the progression of many tumors to malignant disease.
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