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2005 ; ä (ä): 1-40
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Transcriptional regulation
#MMPMID18050428
Okkema PG
; Krause M
WormBook
2005[Dec]; ä (ä): 1-40
PMID18050428
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The regulation of transcription in C. elegans shares many similarities to
transcription in other organisms. The details of how specific transcription
factors bind to target promoters and act as either activators or repressors are
still being examined in many cases, but an increasing number of factors and their
binding sites are being characterized. This chapter reviews the general concepts
that have emerged with regards to promoter function in C. elegans. Included are
the methods that have been successfully employed as well as limitations
encountered to date. Specific cis-acting promoter elements from myo-2, hlh-1 and
lin-26 are discussed as examples of complex promoters regulated by multiple
sequence elements. In addition, examples of organ-, tissue-, and cell
type-specific mechanisms for generating spatial specificity in gene expression
are discussed.