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10.1016/j.semcdb.2014.05.010 http://scihub22266oqcxt.onion/10.1016/j.semcdb.2014.05.010 C4130763!4130763 !24862856     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24862856 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Semin+Cell+Dev+Biol 2014 ; 33 (?): 73-80 Nephropedia Template TP {{tp|p=24862856 |t=2014. Transcriptional regulation of graded Hedgehog signaling |pdf=|usr=}}{{24862856 }} gab.com Text Transcriptional regulation of graded Hedgehog signaling JO: Semin Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=24862856 #FOAvip The Hedgehog (Hh) pathway plays conserved roles in regulating a diverse spectrum of developmental processes. In some developmental contexts, a gradient of Hh protein specifies multiple cell types in a dose-dependent fashion, thereby acting as a morphogen. Hh signaling ultimately acts on the transcriptional level through GLI proteins. In the presence of Hh signaling full length GLI proteins act as transcriptional activators of target genes. Conversely, in the absence of Hh, GLI proteins act as transcriptional repressors. This review will highlight mechanisms contributing to how graded Hh signaling might translate to differential GLI activity and be interpreted into distinct transcriptional responses. Twit Text FOAVip Transcriptional regulation of graded Hedgehog signaling ????Semin Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=24862856 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24862856 #FOAvip English Wikipedia <ref>{{Cite pmid|24862856 }}</ref> Transcriptional regulation of graded Hedgehog signaling #MMPMID24862856 Falkenstein KN ; Vokes SA Semin Cell Dev Biol 2014[Sep]; 33 (?): 73-80 PMID24862856 show ga The Hedgehog (Hh) pathway plays conserved roles in regulating a diverse spectrum of developmental processes. In some developmental contexts, a gradient of Hh protein specifies multiple cell types in a dose-dependent fashion, thereby acting as a morphogen. Hh signaling ultimately acts on the transcriptional level through GLI proteins. In the presence of Hh signaling full length GLI proteins act as transcriptional activators of target genes. Conversely, in the absence of Hh, GLI proteins act as transcriptional repressors. This review will highlight mechanisms contributing to how graded Hh signaling might translate to differential GLI activity and be interpreted into distinct transcriptional responses. |*Gene Expression Regulation, Developmental [MESH] |Animals [MESH] |Binding Sites [MESH] |Body Patterning [MESH] |Hedgehog Proteins/*physiology [MESH] |Organ Specificity [MESH] |Phosphorylation [MESH] |Protein Binding [MESH] |Protein Processing, Post-Translational [MESH] |Signal Transduction [MESH]Transcriptional regulation of graded Hedgehog signaling (epmc).pdf DeepDyve Pubget Overpricing