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Transcriptional regulation and development of regulatory T cells
#MMPMID29520112
Lee W
; Lee GR
Exp Mol Med
2018[Mar]; 50
(3
): e456
PMID29520112
show ga
Regulatory T (Treg) cells are a distinct subset of CD4(+) T cells. Instead of
triggering adaptive immunity, they suppress immune responses. Small numbers of
Treg cells reside within lymphoid organs and peripheral tissues, but their
contribution to immune tolerance is so significant that defects in Treg cell
function cause catastrophic immune disorders. Since they were first discovered 20
years ago, efforts have been made to understand the differences in developmental
processes between Treg cells and conventional T cells that determine the ultimate
fate of the overall T-cell population. Transcription factor Foxp3 is crucial for
Treg cell differentiation, but it is not the whole story. Owing to recent
advances in Treg cell research, we are now on the verge of appreciating the
comprehensive mechanisms underlying Treg cell generation. Here, we discuss major
discoveries, active study topics and remaining questions regarding Treg cell
development.
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