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10.1038/s41598-018-24509-6 http://scihub22266oqcxt.onion/10.1038/s41598-018-24509-6 C5928056!5928056 !29712924     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29712924 &cmd=llinks): Failed to open stream: HTTP request failed! 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Transcriptional landscape of Mycobacterium tuberculosis infection in macrophages |pdf=|usr=}}{{29712924 }} gab.com Text Transcriptional landscape of Mycobacterium tuberculosis infection in macrophages JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29712924 #FOAvip Mycobacterium tuberculosis (Mtb) infection reveals complex and dynamic host-pathogen interactions, leading to host protection or pathogenesis. Using a unique transcriptome technology (CAGE), we investigated the promoter-based transcriptional landscape of IFN? (M1) or IL-4/IL-13 (M2) stimulated macrophages during Mtb infection in a time-kinetic manner. Mtb infection widely and drastically altered macrophage-specific gene expression, which is far larger than that of M1 or M2 activations. Gene Ontology enrichment analysis for Mtb-induced differentially expressed genes revealed various terms, related to host-protection and inflammation, enriched in up-regulated genes. On the other hand, terms related to dis-regulation of cellular functions were enriched in down-regulated genes. Differential expression analysis revealed known as well as novel transcription factor genes in Mtb infection, many of them significantly down-regulated. IFN? or IL-4/IL-13 pre-stimulation induce additional differentially expressed genes in Mtb-infected macrophages. Cluster analysis uncovered significant numbers, prolonging their expressional changes. Furthermore, Mtb infection augmented cytokine-mediated M1 and M2 pre-activations. In addition, we identified unique transcriptional features of Mtb-mediated differentially expressed lncRNAs. In summary we provide a comprehensive in depth gene expression/regulation profile in Mtb-infected macrophages, an important step forward for a better understanding of host-pathogen interaction dynamics in Mtb infection. Twit Text FOAVip Transcriptional landscape of Mycobacterium tuberculosis infection in macrophages ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29712924 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29712924 #FOAvip English Wikipedia <ref>{{Cite pmid|29712924 }}</ref> Transcriptional landscape of Mycobacterium tuberculosis infection in macrophages #MMPMID29712924 Roy S ; Schmeier S ; Kaczkowski B ; Arner E ; Alam T ; Ozturk M ; Tamgue O ; Parihar SP ; Kawaji H ; Itoh M ; Lassmann T ; Carninci P ; Hayashizaki Y ; Forrest ARR ; Guler R ; Bajic VB ; Brombacher F ; Suzuki H Sci Rep 2018[Apr]; 8 (1 ): 6758 PMID29712924 show ga Mycobacterium tuberculosis (Mtb) infection reveals complex and dynamic host-pathogen interactions, leading to host protection or pathogenesis. Using a unique transcriptome technology (CAGE), we investigated the promoter-based transcriptional landscape of IFN? (M1) or IL-4/IL-13 (M2) stimulated macrophages during Mtb infection in a time-kinetic manner. Mtb infection widely and drastically altered macrophage-specific gene expression, which is far larger than that of M1 or M2 activations. Gene Ontology enrichment analysis for Mtb-induced differentially expressed genes revealed various terms, related to host-protection and inflammation, enriched in up-regulated genes. On the other hand, terms related to dis-regulation of cellular functions were enriched in down-regulated genes. Differential expression analysis revealed known as well as novel transcription factor genes in Mtb infection, many of them significantly down-regulated. IFN? or IL-4/IL-13 pre-stimulation induce additional differentially expressed genes in Mtb-infected macrophages. Cluster analysis uncovered significant numbers, prolonging their expressional changes. Furthermore, Mtb infection augmented cytokine-mediated M1 and M2 pre-activations. In addition, we identified unique transcriptional features of Mtb-mediated differentially expressed lncRNAs. In summary we provide a comprehensive in depth gene expression/regulation profile in Mtb-infected macrophages, an important step forward for a better understanding of host-pathogen interaction dynamics in Mtb infection. |*Transcription, Genetic [MESH] |Gene Expression Regulation, Bacterial/genetics [MESH] |Host-Pathogen Interactions/*genetics [MESH] |Humans [MESH] |Interferon-gamma/genetics [MESH] |Interleukin-13/genetics [MESH] |Interleukin-4/genetics [MESH] |Macrophages/microbiology [MESH] |Mycobacterium tuberculosis/*genetics/pathogenicity [MESH] |Promoter Regions, Genetic [MESH] |RNA, Long Noncoding/genetics [MESH] |Transcriptome/genetics [MESH]Transcriptional landscape of Mycobacterium tuberculosis infection in m(epmc).pdf DeepDyve Pubget Overpricing