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2017 ; 1
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Transcriptional Regulation of the First Cell Fate Decision
#MMPMID29658952
Rhee C
; Kim J
; Tucker HO
J Dev Biol Regen Med
2017[]; 1
(1
): ä PMID29658952
show ga
Understanding how the first cell fate decision has chosen is a fascinating
biological question that was received consider attention over the last decade.
Numerous transcription factors are required, and many have been shown to have
essential roles in this process. Here we reexamine the function that
transcription factors play primarily in the mouse-the model system most
thoroughly examined in this process. We address how the first embryonic lineage
is established and maintained, with a particular emphasis on subsequent
trophectoderm development and the role of the recently established Arid3a
transcription factor in this process. In addition, we review relevant aspects of
embryonic stem cell reprogramming into trophoblast stem cells -the equivalent of
the epiblast (inner cell mass) and the establishment of induced trophoblast stem
cells-the in vitro equivalent of the trophectoderm.