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2015 ; 6
(ä): 533
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Transcriptional Regulation of Mononuclear Phagocyte Development
#MMPMID26539196
Tussiwand R
; Gautier EL
Front Immunol
2015[]; 6
(ä): 533
PMID26539196
show ga
Mononuclear phagocytes (MP) are a quite unique subset of hematopoietic cells,
which comprise dendritic cells (DC), monocytes as well as monocyte-derived and
tissue-resident macrophages. These cells are extremely diverse with regard to
their origin, their phenotype as well as their function. Developmentally, DC and
monocytes are constantly replenished from a bone marrow hematopoietic progenitor.
The ontogeny of macrophages is more complex and is temporally linked and
specified by the organ where they reside, occurring early during embryonic or
perinatal life. The functional heterogeneity of MPs is certainly a consequence of
the tissue of residence and also reflects the diverse ontogeny of the subsets. In
this review, we will highlight the developmental pathways of murine MP, with a
particular emphasis on the transcriptional factors that regulate their
development and function. Finally, we will discuss and point out open questions
in the field.