Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1371/journal.pgen.1005606 http://scihub22266oqcxt.onion/10.1371/journal.pgen.1005606 C4618523!4618523 !26484664     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26484664 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+Genet 2015 ; 11 (10 ): e1005606 Nephropedia Template TP {{tp|p=26484664 |t=2015. Transcriptional Derepression Uncovers Cryptic Higher-Order Genetic Interactions |pdf=|usr=}}{{26484664 }} gab.com Text Transcriptional Derepression Uncovers Cryptic Higher-Order Genetic Interactions JO: PLoS Genet http://www.kidney.de/pget.php?&tw=1&pmid=26484664 #FOAvip Disruption of certain genes can reveal cryptic genetic variants that do not typically show phenotypic effects. Because this phenomenon, which is referred to as 'phenotypic capacitance', is a potential source of trait variation and disease risk, it is important to understand how it arises at the genetic and molecular levels. Here, we use a cryptic colony morphology trait that segregates in a yeast cross to explore the mechanisms underlying phenotypic capacitance. We find that the colony trait is expressed when a mutation in IRA2, a negative regulator of the Ras pathway, co-occurs with specific combinations of cryptic variants in six genes. Four of these genes encode transcription factors that act downstream of the Ras pathway, indicating that the phenotype involves genetically complex changes in the transcriptional regulation of Ras targets. We provide evidence that the IRA2 mutation reveals the phenotypic effects of the cryptic variants by disrupting the transcriptional silencing of one or more genes that contribute to the trait. Supporting this role for the IRA2 mutation, deletion of SFL1, a repressor that acts downstream of the Ras pathway, also reveals the phenotype, largely due to the same cryptic variants that were detected in the IRA2 mutant cross. Our results illustrate how higher-order genetic interactions among mutations and cryptic variants can result in phenotypic capacitance in specific genetic backgrounds, and suggests these interactions might reflect genetically complex changes in gene expression that are usually suppressed by negative regulation. Twit Text FOAVip Transcriptional Derepression Uncovers Cryptic Higher-Order Genetic Interactions ????PLoS Genet http://www.kidney.de/pget.php?&tw=1&pmid=26484664 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26484664 #FOAvip English Wikipedia <ref>{{Cite pmid|26484664 }}</ref> Transcriptional Derepression Uncovers Cryptic Higher-Order Genetic Interactions #MMPMID26484664 Taylor MB ; Ehrenreich IM PLoS Genet 2015[Oct]; 11 (10 ): e1005606 PMID26484664 show ga Disruption of certain genes can reveal cryptic genetic variants that do not typically show phenotypic effects. Because this phenomenon, which is referred to as 'phenotypic capacitance', is a potential source of trait variation and disease risk, it is important to understand how it arises at the genetic and molecular levels. Here, we use a cryptic colony morphology trait that segregates in a yeast cross to explore the mechanisms underlying phenotypic capacitance. We find that the colony trait is expressed when a mutation in IRA2, a negative regulator of the Ras pathway, co-occurs with specific combinations of cryptic variants in six genes. Four of these genes encode transcription factors that act downstream of the Ras pathway, indicating that the phenotype involves genetically complex changes in the transcriptional regulation of Ras targets. We provide evidence that the IRA2 mutation reveals the phenotypic effects of the cryptic variants by disrupting the transcriptional silencing of one or more genes that contribute to the trait. Supporting this role for the IRA2 mutation, deletion of SFL1, a repressor that acts downstream of the Ras pathway, also reveals the phenotype, largely due to the same cryptic variants that were detected in the IRA2 mutant cross. Our results illustrate how higher-order genetic interactions among mutations and cryptic variants can result in phenotypic capacitance in specific genetic backgrounds, and suggests these interactions might reflect genetically complex changes in gene expression that are usually suppressed by negative regulation. |*Polymorphism, Genetic [MESH] |*Transcription, Genetic [MESH] |Alleles [MESH] |Gene Expression Regulation, Fungal [MESH] |Membrane Glycoproteins/biosynthesis/*genetics [MESH] |Mutation [MESH] |Phenotype [MESH] |Saccharomyces cerevisiae [MESH] |Saccharomyces cerevisiae Proteins/biosynthesis/*genetics [MESH] |Signal Transduction [MESH]Transcriptional Derepression Uncovers Cryptic Higher-Order Genetic Int(epmc).pdf DeepDyve Pubget Overpricing