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10.1093/database/baw052 http://scihub22266oqcxt.onion/10.1093/database/baw052 C4830474!4830474 !27074805     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27074805 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27074805 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Database+(Oxford) 2016 ; 2016 (ä): ä Nephropedia Template TP {{tp|p=27074805 |t=2016. ToxDB: pathway-level interpretation of drug-treatment data |pdf=|usr=}}{{27074805 }} gab.com Text ToxDB: pathway-level interpretation of drug-treatment data JO: Database (Oxford) http://www.kidney.de/pget.php?&tw=1&pmid=27074805 #FOAvip MOTIVATION: Extensive drug treatment gene expression data have been generated in order to identify biomarkers that are predictive for toxicity or to classify compounds. However, such patterns are often highly variable across compounds and lack robustness. We and others have previously shown that supervised expression patterns based on pathway concepts rather than unsupervised patterns are more robust and can be used to assess toxicity for entire classes of drugs more reliably. RESULTS: We have developed a database, ToxDB, for the analysis of the functional consequences of drug treatment at the pathway level. We have collected 2694 pathway concepts and computed numerical response scores of these pathways for 437 drugs and chemicals and 7464 different experimental conditions. ToxDB provides functionalities for exploring these pathway responses by offering tools for visualization and differential analysis allowing for comparisons of different treatment parameters and for linking this data with toxicity annotation and chemical information.Database URL:http://toxdb.molgen.mpg.de. Twit Text FOAVip ToxDB: pathway-level interpretation of drug-treatment data ????Database (Oxford) http://www.kidney.de/pget.php?&tw=1&pmid=27074805 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27074805 #FOAvip English Wikipedia <ref>{{Cite pmid|27074805 }}</ref> ToxDB: pathway-level interpretation of drug-treatment data #MMPMID27074805 Hardt C ; Beber ME ; Rasche A ; Kamburov A ; Hebels DG ; Kleinjans JC ; Herwig R Database (Oxford) 2016[]; 2016 (ä): ä PMID27074805 show ga MOTIVATION: Extensive drug treatment gene expression data have been generated in order to identify biomarkers that are predictive for toxicity or to classify compounds. However, such patterns are often highly variable across compounds and lack robustness. We and others have previously shown that supervised expression patterns based on pathway concepts rather than unsupervised patterns are more robust and can be used to assess toxicity for entire classes of drugs more reliably. RESULTS: We have developed a database, ToxDB, for the analysis of the functional consequences of drug treatment at the pathway level. We have collected 2694 pathway concepts and computed numerical response scores of these pathways for 437 drugs and chemicals and 7464 different experimental conditions. ToxDB provides functionalities for exploring these pathway responses by offering tools for visualization and differential analysis allowing for comparisons of different treatment parameters and for linking this data with toxicity annotation and chemical information.Database URL:http://toxdb.molgen.mpg.de. |*Databases, Genetic [MESH] |*Databases, Pharmaceutical [MESH] |*Pharmacology [MESH] |Animals [MESH] |Computational Biology [MESH] |Gene Expression Profiling/*methods [MESH] |Gene Expression/*drug effects [MESH] |Humans [MESH] |Internet [MESH] |Rats [MESH]ToxDB: pathway-level interpretation of drug-treatment data (epmc).pdf DeepDyve Pubget Overpricing