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2013 ; 1060
(ä): 68-73
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Towards a Consistent and Scientifically Accurate Drug Ontology
#MMPMID27867326
Hogan WR
; Hanna J
; Joseph E
; Brochhausen M
CEUR Workshop Proc
2013[]; 1060
(ä): 68-73
PMID27867326
show ga
Our use case for comparative effectiveness research requires an ontology of drugs
that enables querying National Drug Codes (NDCs) by active ingredient, mechanism
of action, physiological effect, and therapeutic class of the drug products they
represent. We conducted an ontological analysis of drugs from the realist
perspective, and evaluated existing drug terminology, ontology, and database
artifacts from (1) the technical perspective, (2) the perspective of pharmacology
and medical science (3) the perspective of description logic semantics (if they
were available in Web Ontology Language or OWL), and (4) the perspective of our
realism-based analysis of the domain. No existing resource was sufficient.
Therefore, we built the Drug Ontology (DrOn) in OWL, which we populated with NDCs
and other classes from RxNorm using only content created by the National Library
of Medicine. We also built an application that uses DrOn to query for NDCs as
outlined above, available at: http://ingarden.uams.edu/ingredients. The
application uses an OWL-based description logic reasoner to execute end-user
queries. DrOn is available at http://code.google.com/p/dr-on.