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2016 ; 17
(8
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Towards Effective Photothermal/Photodynamic Treatment Using Plasmonic Gold
Nanoparticles
#MMPMID27517913
Bucharskaya A
; Maslyakova G
; Terentyuk G
; Yakunin A
; Avetisyan Y
; Bibikova O
; Tuchina E
; Khlebtsov B
; Khlebtsov N
; Tuchin V
Int J Mol Sci
2016[Aug]; 17
(8
): ä PMID27517913
show ga
Gold nanoparticles (AuNPs) of different size and shape are widely used as
photosensitizers for cancer diagnostics and plasmonic photothermal
(PPT)/photodynamic (PDT) therapy, as nanocarriers for drug delivery and
laser-mediated pathogen killing, even the underlying mechanisms of treatment
effects remain poorly understood. There is a need in analyzing and improving the
ways to increase accumulation of AuNP in tumors and other crucial steps in
interaction of AuNPs with laser light and tissues. In this review, we summarize
our recent theoretical, experimental, and pre-clinical results on light activated
interaction of AuNPs with tissues and cells. Specifically, we discuss a combined
PPT/PDT treatment of tumors and killing of pathogen bacteria with gold-based
nanocomposites and atomic clusters, cell optoporation, and theoretical
simulations of nanoparticle-mediated laser heating of tissues and cells.