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10.1042/BST20160085

http://scihub22266oqcxt.onion/10.1042/BST20160085
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C5095900!5095900 !27911730
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suck abstract from ncbi


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pmid27911730
      Biochem+Soc+Trans 2016 ; 44 (5 ): 1483-1490
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  • Toward a therapy for mitochondrial disease #MMPMID27911730
  • Viscomi C
  • Biochem Soc Trans 2016[Oct]; 44 (5 ): 1483-1490 PMID27911730 show ga
  • Mitochondrial disorders are a group of genetic diseases affecting the energy-converting process of oxidative phosphorylation. The extreme variability of symptoms, organ involvement, and clinical course represent a challenge to the development of effective therapeutic interventions. However, new possibilities have recently been emerging from studies in model organisms and awaiting verification in humans. I will discuss here the most promising experimental approaches and the challenges we face to translate them into the clinics. The current clinical trials will also be briefly reviewed.
  • |Animals [MESH]
  • |Clinical Trials as Topic [MESH]
  • |DNA, Mitochondrial/*genetics/metabolism [MESH]
  • |Energy Metabolism/genetics [MESH]
  • |Humans [MESH]
  • |Mitochondria/*genetics/metabolism [MESH]
  • |Mitochondrial Diseases/*genetics/metabolism/*therapy [MESH]
  • |Outcome Assessment, Health Care [MESH]
  • |Reactive Oxygen Species/metabolism [MESH]


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