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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Biochem+Soc+Trans
2016 ; 44
(5
): 1483-1490
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Toward a therapy for mitochondrial disease
#MMPMID27911730
Viscomi C
Biochem Soc Trans
2016[Oct]; 44
(5
): 1483-1490
PMID27911730
show ga
Mitochondrial disorders are a group of genetic diseases affecting the
energy-converting process of oxidative phosphorylation. The extreme variability
of symptoms, organ involvement, and clinical course represent a challenge to the
development of effective therapeutic interventions. However, new possibilities
have recently been emerging from studies in model organisms and awaiting
verification in humans. I will discuss here the most promising experimental
approaches and the challenges we face to translate them into the clinics. The
current clinical trials will also be briefly reviewed.