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2018 ; 3
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gab.com Text
Twit Text FOAVip
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English Wikipedia
Toward Personalized Control of Human Gut Bacterial Communities
#MMPMID29629415
David LA
mSystems
2018[Mar]; 3
(2
): ä PMID29629415
show ga
A key challenge in microbiology will be developing tools for manipulating human
gut bacterial communities. Our ability to predict and control the dynamics of
these communities is now in its infancy. To manage human gut microbiota, I am
developing methods in three research domains. First, I am refining in vitro tools
to experimentally study gut microbes at high throughput and in controlled
settings. Second, I am adapting "big data" techniques to overcome statistical
challenges confronting microbiota modeling. Third, I am testing study designs
that can streamline human testing of microbiota manipulations. Assembling these
methods creates new challenges, including training scientists who can work across
disciplines such as engineering, ecology, and medicine. Nevertheless, I envision
that overcoming these obstacles will enable my group to construct platforms that
can personalize microbiota treatments, particularly ones based on diet. More
broadly, I anticipate that such platforms will have applications across fields
such as agriculture, biotechnology, and environmental management.