Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28102431
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Mol+Med+(Berl)
2017 ; 95
(7
): 687-694
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Totipotency in the mouse
#MMPMID28102431
Wu G
; Lei L
; Schöler HR
J Mol Med (Berl)
2017[Jul]; 95
(7
): 687-694
PMID28102431
show ga
In mammals, the unicellular zygote starts the process of embryogenesis and
differentiates into all types of somatic cells, including both fetal and
extraembryonic lineages-in a highly organized manner to eventually give rise to
an entire multicellular organism comprising more than 200 different tissue types.
This feature is referred to as totipotency. Upon fertilization, oocyte maternal
factors epigenetically reprogram the genomes of the terminally differentiated
oocyte and spermatozoon and turn the zygote into a totipotent cell. Today, we
still do not fully understand the molecular properties of totipotency. In this
review, we discuss recent findings on the molecular signature and mechanism of
transcriptional regulation networks in the totipotent mouse embryo.