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2014 ; 25
(6
): 482-6
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Tonsillectomy as a treatment for psoriasis: a review
#MMPMID24283892
Wu W
; Debbaneh M
; Moslehi H
; Koo J
; Liao W
J Dermatolog Treat
2014[Dec]; 25
(6
): 482-6
PMID24283892
show ga
Psoriasis is a chronic skin disorder that affects 1% to 3% of the general
population worldwide. Streptococcal infection, especially streptococcal
pharyngitis, has been shown to be a significant trigger of psoriasis in some
patients, possibly by sensitizing T cells to keratin epitopes in the skin. Due to
the role of the palatine tonsils as an immunological organ that may generate
autoreactive T cells, tonsillectomy has been investigated as a treatment for
psoriasis. Tonsillectomy originally gained acceptance in Japan as a treatment for
palmoplantar pustulosis, a condition that shares features with pustular
psoriasis. Subsequently, tonsillectomy has been used for the treatment of plaque
psoriasis and guttate psoriasis. Recently, the first randomized, controlled
clinical trial of tonsillectomy was performed. Here, we review the available
evidence for the benefit of tonsillectomy as a treatment for palmoplantar
pustulosis and psoriasis. We also discuss molecular studies aimed at
understanding the role of tonsils in skin disease.
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