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10.1093/infdis/jiv270 http://scihub22266oqcxt.onion/10.1093/infdis/jiv270 C4621249!4621249 !25977263     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25977263 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Infect+Dis 2015 ; 212 (10 ): 1666-76 Nephropedia Template TP {{tp|p=25977263 |t=2015. Toll-like Receptor 10 in Helicobacter pylori Infection |pdf=|usr=}}{{25977263 }} gab.com Text Toll-like Receptor 10 in Helicobacter pylori Infection JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=25977263 #FOAvip Innate immunity plays important roles in the primary defense against pathogens, and epidemiological studies have suggested a role for Toll-like receptor 1 (TLR1) in Helicobacter pylori susceptibility. Microarray analysis of gastric biopsy specimens from H. pylori-positive and uninfected subjects showed that TLR10 messenger RNA (mRNA) levels were upregulated approximately 15-fold in infected subjects; these findings were confirmed by real-time quantitative polymerase chain reaction analysis. Immunohistochemical investigation showed increased TLR10 expression in the gastric epithelial cells of infected individuals. When H. pylori was cocultured with NCI-N87 gastric cells, both TLR10 and TLR2 mRNA levels were upregulated. We compared the ability of TLR combinations to mediate nuclear factor-?B (NF-?B) activation. Compared with other TLR2 subfamily heterodimers, the TLR2/TLR10 heterodimer mediated the greatest NF-?B activation following exposure to heat-killed H. pylori or H. pylori lipopolysaccharide. We conclude that TLR10 is a functional receptor involved in the innate immune response to H. pylori infection and that the TLR2/TLR10 heterodimer functions in H. pylori lipopolysaccharide recognition. Twit Text FOAVip Toll-like Receptor 10 in Helicobacter pylori Infection ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=25977263 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25977263 #FOAvip English Wikipedia <ref>{{Cite pmid|25977263 }}</ref> Toll-like Receptor 10 in Helicobacter pylori Infection #MMPMID25977263 Nagashima H ; Iwatani S ; Cruz M ; Jiménez Abreu JA ; Uchida T ; Mahachai V ; Vilaichone RK ; Graham DY ; Yamaoka Y J Infect Dis 2015[Nov]; 212 (10 ): 1666-76 PMID25977263 show ga Innate immunity plays important roles in the primary defense against pathogens, and epidemiological studies have suggested a role for Toll-like receptor 1 (TLR1) in Helicobacter pylori susceptibility. Microarray analysis of gastric biopsy specimens from H. pylori-positive and uninfected subjects showed that TLR10 messenger RNA (mRNA) levels were upregulated approximately 15-fold in infected subjects; these findings were confirmed by real-time quantitative polymerase chain reaction analysis. Immunohistochemical investigation showed increased TLR10 expression in the gastric epithelial cells of infected individuals. When H. pylori was cocultured with NCI-N87 gastric cells, both TLR10 and TLR2 mRNA levels were upregulated. We compared the ability of TLR combinations to mediate nuclear factor-?B (NF-?B) activation. Compared with other TLR2 subfamily heterodimers, the TLR2/TLR10 heterodimer mediated the greatest NF-?B activation following exposure to heat-killed H. pylori or H. pylori lipopolysaccharide. We conclude that TLR10 is a functional receptor involved in the innate immune response to H. pylori infection and that the TLR2/TLR10 heterodimer functions in H. pylori lipopolysaccharide recognition. |Cell Line [MESH] |Coculture Techniques [MESH] |Epithelial Cells/chemistry [MESH] |Gastric Mucosa/pathology [MESH] |Gene Expression Profiling [MESH] |Helicobacter Infections/*immunology [MESH] |Helicobacter pylori/*immunology [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Lipopolysaccharides/immunology [MESH] |Microarray Analysis [MESH] |NF-kappa B/analysis [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Toll-Like Receptor 10/genetics/*metabolism [MESH]Toll-like Receptor 10 in Helicobacter pylori Infection (epmc).pdf DeepDyve Pubget Overpricing