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2015 ; 49
(ä): 735-745
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Titania nanotube arrays as interfaces for neural prostheses
#MMPMID25687003
Sorkin JA
; Hughes S
; Soares P
; Popat KC
Mater Sci Eng C Mater Biol Appl
2015[Apr]; 49
(ä): 735-745
PMID25687003
show ga
Neural prostheses have become ever more acceptable treatments for many different
types of neurological damage and disease. Here we investigate the use of two
different morphologies of titania nanotube arrays as interfaces to advance the
longevity and effectiveness of these prostheses. The nanotube arrays were
characterized for their nanotopography, crystallinity, conductivity, wettability,
surface mechanical properties and adsorption of key proteins: fibrinogen, albumin
and laminin. The loosely packed nanotube arrays fabricated using a diethylene
glycol based electrolyte, contained a higher presence of the anatase crystal
phase and were subsequently more conductive. These arrays yielded surfaces with
higher wettability and lower modulus than the densely packed nanotube arrays
fabricated using water based electrolyte. Further the adhesion, proliferation and
differentiation of the C17.2 neural stem cell line was investigated on the
nanotube arrays. The proliferation ratio of the cells as well as the level of
neuronal differentiation was seen to increase on the loosely packed arrays. The
results indicate that loosely packed nanotube arrays similar to the ones produced
here with a DEG based electrolyte, may provide a favorable template for growth
and maintenance of C17.2 neural stem cell line.