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2017 ; 5
(ä): 41
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Tissue-resident lymphocytes: sentinel of the transformed tissue
#MMPMID28515941
Dadi S
; Li MO
J Immunother Cancer
2017[]; 5
(ä): 41
PMID28515941
show ga
Tumor cells can be detected and cleared by lymphocytes in a process termed cancer
immunosurveillance. However, the contributing cell types had not been fully
characterized. Using oncogene-induced murine models of epithelial cancer, a
recent study showed that cell transformation triggers expansion of
tissue-resident lymphocytes derived from innate, T cell receptor (TCR) ?? and
TCR?? lineages. These type-1-like innate lymphoid cells (ILC1ls) and type 1
innate-like T cells (ILTC1s) share a gene expression program distinct from those
of conventional lymphocytes, and exhibit cytolytic activities against tumor
cells. Further deciphering such a tumor-elicited immunosurveillance mechanism may
1 day be harnessed for novel cancer immunotherapy.