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10.1016/j.trecan.2017.03.003 http://scihub22266oqcxt.onion/10.1016/j.trecan.2017.03.003 C5518481!5518481 !28718438     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28718438 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Cancer 2017 ; 3 (4 ): 259-268 Nephropedia Template TP {{tp|p=28718438 |t=2017. Tissue-Intrinsic Tumor Hotspots: Terroir for Tumorigenesis |pdf=|usr=}}{{28718438 }} gab.com Text Tissue-Intrinsic Tumor Hotspots: Terroir for Tumorigenesis JO: Trends Cancer http://www.kidney.de/pget.php?&tw=1&pmid=28718438 #FOAvip Epithelial tissues are highly organized systems with a remarkable homeostatic ability to maintain morphology through regulation of cellular proliferation and tissue integrity. This robust self-organizing system is progressively disrupted during tumor development. Recent studies of conserved tumor-suppressor genes in Drosophila showed how protumor cells deviate from the robustly organized tissue microenvironment to take the first steps into becoming aggressive tumors. Here we review the 'tumor hotspot' hypothesis that explains how the tissue-intrinsic local microenvironment has a pivotal role in the initial stage of tumorigenesis in Drosophila epithelia and discuss comparable mechanisms in mammalian tissues. Twit Text FOAVip Tissue-Intrinsic Tumor Hotspots: Terroir for Tumorigenesis ????Trends Cancer http://www.kidney.de/pget.php?&tw=1&pmid=28718438 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28718438 #FOAvip English Wikipedia <ref>{{Cite pmid|28718438 }}</ref> Tissue-Intrinsic Tumor Hotspots: Terroir for Tumorigenesis #MMPMID28718438 Tamori Y ; Deng WM Trends Cancer 2017[Apr]; 3 (4 ): 259-268 PMID28718438 show ga Epithelial tissues are highly organized systems with a remarkable homeostatic ability to maintain morphology through regulation of cellular proliferation and tissue integrity. This robust self-organizing system is progressively disrupted during tumor development. Recent studies of conserved tumor-suppressor genes in Drosophila showed how protumor cells deviate from the robustly organized tissue microenvironment to take the first steps into becoming aggressive tumors. Here we review the 'tumor hotspot' hypothesis that explains how the tissue-intrinsic local microenvironment has a pivotal role in the initial stage of tumorigenesis in Drosophila epithelia and discuss comparable mechanisms in mammalian tissues. |Animals [MESH] |Carcinogenesis/*genetics [MESH] |Cell Proliferation [MESH] |Drosophila Proteins/*genetics [MESH] |Drosophila/*genetics [MESH]Tissue-Intrinsic Tumor Hotspots: Terroir for Tumorigenesis (epmc).pdf DeepDyve Pubget Overpricing