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2015 ; 211
(2
): 219-31
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Tissue patterning and cellular mechanics
#MMPMID26504164
Heller E
; Fuchs E
J Cell Biol
2015[Oct]; 211
(2
): 219-31
PMID26504164
show ga
In development, cells organize into biological tissues through cell growth,
migration, and differentiation. Globally, this process is dictated by a
genetically encoded program in which secreted morphogens and cell-cell
interactions prompt the adoption of unique cell fates. Yet, at its lowest level,
development is achieved through the modification of cell-cell adhesion and
actomyosin-based contractility, which set the level of tension within cells and
dictate how they pack together into tissues. The regulation of tension within
individual cells and across large groups of cells is a major driving force of
tissue organization and the basis of all cell shape change and cell movement in
development.
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