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2017 ; 410
(ä): 127-156
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Tim-3, Lag-3, and TIGIT
#MMPMID28900677
Joller N
; Kuchroo VK
Curr Top Microbiol Immunol
2017[]; 410
(ä): 127-156
PMID28900677
show ga
Co-inhibitory receptors play a key role in regulating T cell responses and
maintaining immune homeostasis. Their inhibitory function prevents autoimmune
responses but also restricts the ability of T cells to mount effective immune
responses against tumors or persistent pathogens. T cells express a module of
co-inhibitory receptors, which display great diversity in expression, structure,
and function. Here, we focus on the co-inhibitory receptors Tim-3, Lag-3, and
TIGIT and how they regulate T cell function, maintenance of self-tolerance, their
role in regulating ongoing T cell responses at peripheral tissues, and their
synergistic effects in regulating autoimmunity and antitumor responses.
|*Autoimmunity
[MESH]
|*Hepatitis A Virus Cellular Receptor 2/physiology
[MESH]