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2016 ; 5
(1
): ä Nephropedia Template TP
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Thyroid Cancer Metabolism: A Review
#MMPMID27213120
Gill KS
; Tassone P
; Hamilton J
; Hjelm N
; Luginbuhl A
; Cognetti D
; Tuluc M
; Martinez-Outschoorn U
; Johnson JM
; Curry JM
J Thyroid Disord Ther
2016[Feb]; 5
(1
): ä PMID27213120
show ga
Metabolic dysregulation within the tumor microenvironment (TME) is critical to
the process of tumorigenesis in various cancer types. Thyrocyte metabolism in
papillary and anaplastic thyroid cancer, however, remains poorly characterized,
and studies analyzing the role of multicompartment metabolism in thyrocyte
oncogenesis are sparse. We present a review of the current knowledge on cellular
metabolism in non-cancerous and cancerous thyroid tissues, focusing on the
monocarboxylate transporters MCT1 and MCT4, and on a transporter of the outer
mitochondrial membrane TOMM20. Understanding the metabolic phenotype of tumor
cells and associated stromal cells in thyroid cancer can have profound
implications on the use of biomarker staining in detecting subclinical cancer,
imaging as it relates to expression of various transport proteins, and
therapeutic interventions that manipulate this dysregulated tumor metabolism to
halt tumorigenesis and eradicate the cancer. Future studies are required to
confirm the prognostic significance of these biomarkers and their correlation
with existing staging schemas such as the AGES, AMES, ATA and MACIS scoring
systems.
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