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2013 ; 43
(6
): 1425-9
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Thymus-homing dendritic cells in central tolerance
#MMPMID23616226
Hadeiba H
; Butcher EC
Eur J Immunol
2013[Jun]; 43
(6
): 1425-9
PMID23616226
show ga
Central tolerance is critical in establishing a peripheral T-cell repertoire
purged of functional autoreactive T cells. One of the major requirements for
effective central tolerance is the presentation of self and other innocuous
antigens (Ags), including food, gut flora, or airway allergens, to developing T
cells in the thymus. This seemingly challenging task can be mediated in some
cases by ectopic expression of tissue-specific Ags by thymic epithelial cells or
by entry of systemic blood-borne Ags into the thymus. More recently, thymic
homing peripheral dendritic cells (DCs) have been proposed as cellular
transporters of peripheral tissue-specific Ags or foreign innocuous Ags. The aim
of this viewpoint is to discuss the three principal thymic DC populations and
their trafficking properties in the context of central tolerance. We will first
discuss the importance of peripheral DC trafficking to the thymus and then
compare and contrast the three DC subsets. We will describe how they were
characterized, describe their trafficking to and their microenvironmental
positioning in the thymus, and discuss the functional consequence of thymic
trafficking and localization on thymic selection events.
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