Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25972479
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Immunol
2015 ; 194
(12
): 5861-71
Nephropedia Template TP
Kang BH
; Park HJ
; Yum HI
; Park SP
; Park JK
; Kang EH
; Lee JI
; Lee EB
; Park CG
; Jung KC
; Park SH
J Immunol
2015[Jun]; 194
(12
): 5861-71
PMID25972479
show ga
Identification of intrathymic eomesodermin(+) (Eomes(+)) CD4 T cells creates a
novel idea that there is more than one way for the generation of innate CD4 T
cells. Promyelocytic leukemia zinc finger protein(+) T cells and natural Th17
cells are known to be generated by sensing a high and persistent TCR strength,
whereas this is not the case for Eomes(+) CD4 T cells. These cells go through
low-level signal during the entire maturation pathway, which subsequently leads
to induction of high susceptibility to cytokine IL-4. This event seems to be a
major determinant for the generation of this type of cell. These T cells are
functionally equivalent to Th1 cells that are present in the periphery, and this
event takes place both in transgenic and in wild-type mice. There is additional
evidence that this type of Eomes(+) innate CD4 T cell is also present in human
cord blood.
free
free
free
