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10.1038/onc.2017.140 http://scihub22266oqcxt.onion/10.1038/onc.2017.140 C5589494!5589494!28481870     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28481870.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncogene 2017 ; 36 (36): 5189-98 Nephropedia Template TP {{tp|p=28481870|t=2017. Thrombospondin-4 mediates TGF-?-induced angiogenesis |pdf=|usr=}}{{28481870}} gab.com Text Thrombospondin-4 mediates TGF- -induced angiogenesis JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=28481870 #FOAvip TGF-? is a multifunctional cytokine affecting many cell types and implicated in tissue remodeling processes. Due to its many functions and cell-specific effects, the consequences of TGF-? signaling are process-and stage-dependent, and it is not uncommon that TGF-? exerts distinct and sometimes opposing effects on a disease progression depending on the stage and on the pathological changes associated with the stage. The mechanisms underlying cell- and process-specific effects of TGF-? are poorly understood.We are describing a novel pathway that mediates induction of angiogenesis in response to TGF-?1. We found that in endothelial cells (EC) TSP-4, a secreted extracellular matrix (ECM) protein is upregulated in response to TGF-?1 and mediates the effects of TGF-?1 on angiogenesis.Upregulation of TSP-4 does not require the synthesis of new protein, is not caused by decreased secretion of TSP-4, and is mediated by activation of SMAD3. Using Thbs4?/? mice and TSP-4 shRNA, we found that TSP-4 mediated pro-angiogenic functions on cultured EC and angiogenesis in vivo in response to TGF-?1. We observed ~ 3-fold increases in tumor mass and levels of angiogenesis markers in animals injected with TGF-?1, and these effects did not occur in Thbs4?/? animals. Injections of an inhibitor of TGF-?1 signaling SB431542 also decreased the weights of tumors and cancer angiogenesis.Our results from in vivo angiogenesis models and cultured EC document that TSP-4 mediates upregulation of angiogenesis by TGF-?1. Upregulation of pro-angiogenic TSP-4 and selective effects of TSP-4 on EC may contribute to stimulation of tumor growth by TGF-? despite the inhibition of cancer cell proliferation. Twit Text FOAVip Thrombospondin-4 mediates TGF- -induced angiogenesis ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=28481870 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28481870 #FOAvip English Wikipedia <ref>{{Cite pmid|28481870}}</ref> Thrombospondin-4 mediates TGF-?-induced angiogenesis #MMPMID28481870 Muppala S; Xiao R; Krukovets I; Verbovetsky D; Yendamuri R; Habib N; Raman P; Plow E; Stenina-Adognravi O Oncogene 2017[Sep]; 36 (36): 5189-98 PMID28481870show ga TGF-? is a multifunctional cytokine affecting many cell types and implicated in tissue remodeling processes. Due to its many functions and cell-specific effects, the consequences of TGF-? signaling are process-and stage-dependent, and it is not uncommon that TGF-? exerts distinct and sometimes opposing effects on a disease progression depending on the stage and on the pathological changes associated with the stage. The mechanisms underlying cell- and process-specific effects of TGF-? are poorly understood.We are describing a novel pathway that mediates induction of angiogenesis in response to TGF-?1. We found that in endothelial cells (EC) TSP-4, a secreted extracellular matrix (ECM) protein is upregulated in response to TGF-?1 and mediates the effects of TGF-?1 on angiogenesis.Upregulation of TSP-4 does not require the synthesis of new protein, is not caused by decreased secretion of TSP-4, and is mediated by activation of SMAD3. Using Thbs4?/? mice and TSP-4 shRNA, we found that TSP-4 mediated pro-angiogenic functions on cultured EC and angiogenesis in vivo in response to TGF-?1. We observed ~ 3-fold increases in tumor mass and levels of angiogenesis markers in animals injected with TGF-?1, and these effects did not occur in Thbs4?/? animals. Injections of an inhibitor of TGF-?1 signaling SB431542 also decreased the weights of tumors and cancer angiogenesis.Our results from in vivo angiogenesis models and cultured EC document that TSP-4 mediates upregulation of angiogenesis by TGF-?1. Upregulation of pro-angiogenic TSP-4 and selective effects of TSP-4 on EC may contribute to stimulation of tumor growth by TGF-? despite the inhibition of cancer cell proliferation. äThrombospondin-4 mediates TGF-?-induced angiogenesis (epmc).pdf DeepDyve Pubget Overpricing