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2015 ; 31
(7
): 366-70
Nephropedia Template TP
J Ocul Pharmacol Ther
2015[Sep]; 31
(7
): 366-70
PMID26352160
show ga
Ocular angiogenesis is one of the underlying causes of blindness and vision
impairment and may occur in a spectrum of disorders, including diabetic
retinopathy, neovascular age-related macular degeneration, retinal artery or vein
occlusion, and retinopathy of prematurity. As such, strategies to inhibit
angiogenesis by suppressing vascular endothelial growth factor activity have
proven to be effective in the clinic for the treatment of eye diseases. A
complementary approach would be to increase the level of naturally occurring
inhibitors of angiogenesis, such as thrombospondin (TSP)-1. This article
summarizes the development of TSP-1-based inhibitors of angiogenesis.
|Angiogenesis Inhibitors/adverse effects/pharmacology/*therapeutic use
[MESH]