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2015 ; 13
(ä): 15
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Thrombosis in vasculitis: from pathogenesis to treatment
#MMPMID25883536
Emmi G
; Silvestri E
; Squatrito D
; Amedei A
; Niccolai E
; D'Elios MM
; Della Bella C
; Grassi A
; Becatti M
; Fiorillo C
; Emmi L
; Vaglio A
; Prisco D
Thromb J
2015[]; 13
(ä): 15
PMID25883536
show ga
In recent years, the relationship between inflammation and thrombosis has been
deeply investigated and it is now clear that immune and coagulation systems are
functionally interconnected. Inflammation-induced thrombosis is by now considered
a feature not only of autoimmune rheumatic diseases, but also of systemic
vasculitides such as Behçet's syndrome, ANCA-associated vasculitis or giant cells
arteritis, especially during active disease. These findings have important
consequences in terms of management and treatment. Indeed, Behçet'syndrome
requires immunosuppressive agents for vascular involvement rather than
anticoagulation or antiplatelet therapy, and it is conceivable that also in
ANCA-associated vasculitis or large vessel-vasculitis an aggressive
anti-inflammatory treatment during active disease could reduce the risk of
thrombotic events in early stages. In this review we discuss thrombosis in
vasculitides, especially in Behçet's syndrome, ANCA-associated vasculitis and
large-vessel vasculitis, and provide pathogenetic and clinical clues for the
different specialists involved in the care of these patients.