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2015 ; 6
(4
): 241-53
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Three-dimensional regulation of transcription
#MMPMID25670626
Cao J
; Luo Z
; Cheng Q
; Xu Q
; Zhang Y
; Wang F
; Wu Y
; Song X
Protein Cell
2015[Apr]; 6
(4
): 241-53
PMID25670626
show ga
Cells can adapt to environment and development by reconstructing their
transcriptional networks to regulate diverse cellular processes without altering
the underlying DNA sequences. These alterations, namely epigenetic changes, occur
during cell division, differentiation and cell death. Numerous evidences
demonstrate that epigenetic changes are governed by various types of
determinants, including DNA methylation patterns, histone posttranslational
modification signatures, histone variants, chromatin remodeling, and recently
discovered chromosome conformation characteristics and non-coding RNAs (ncRNAs).
Here, we highlight recent efforts on how the two latter epigenetic factors
participate in the sophisticated transcriptional process and describe emerging
techniques which permit us to uncover and gain insights into the fascinating
genomic regulation.
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