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10.1038/srep15205 http://scihub22266oqcxt.onion/10.1038/srep15205 C4607978!4607978 !26471876     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26471876 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 15205 Nephropedia Template TP {{tp|p=26471876 |t=2015. Three-dimensional chemotaxis-driven aggregation of tumor cells |pdf=|usr=}}{{26471876 }} gab.com Text Three-dimensional chemotaxis-driven aggregation of tumor cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26471876 #FOAvip One of the most important steps in tumor progression involves the transformation from a differentiated epithelial phenotype to an aggressive, highly motile phenotype, where tumor cells invade neighboring tissues. Invasion can occur either by isolated mesenchymal cells or by aggregates that migrate collectively and do not lose completely the epithelial phenotype. Here, we show that, in a three-dimensional cancer cell culture, collective migration of cells eventually leads to aggregation in large clusters. We present quantitative measurements of cluster velocity, coalescence rates, and proliferation rates. These results cannot be explained in terms of random aggregation. Instead, a model of chemotaxis-driven aggregation - mediated by a diffusible attractant - is able to capture several quantitative aspects of our results. Experimental assays of chemotaxis towards culture conditioned media confirm this hypothesis. Theoretical and numerical results further suggest an important role for chemotactic-driven aggregation in spreading and survival of tumor cells. Twit Text FOAVip Three-dimensional chemotaxis-driven aggregation of tumor cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26471876 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26471876 #FOAvip English Wikipedia <ref>{{Cite pmid|26471876 }}</ref> Three-dimensional chemotaxis-driven aggregation of tumor cells #MMPMID26471876 Puliafito A ; De Simone A ; Seano G ; Gagliardi PA ; Di Blasio L ; Chianale F ; Gamba A ; Primo L ; Celani A Sci Rep 2015[Oct]; 5 (ä): 15205 PMID26471876 show ga One of the most important steps in tumor progression involves the transformation from a differentiated epithelial phenotype to an aggressive, highly motile phenotype, where tumor cells invade neighboring tissues. Invasion can occur either by isolated mesenchymal cells or by aggregates that migrate collectively and do not lose completely the epithelial phenotype. Here, we show that, in a three-dimensional cancer cell culture, collective migration of cells eventually leads to aggregation in large clusters. We present quantitative measurements of cluster velocity, coalescence rates, and proliferation rates. These results cannot be explained in terms of random aggregation. Instead, a model of chemotaxis-driven aggregation - mediated by a diffusible attractant - is able to capture several quantitative aspects of our results. Experimental assays of chemotaxis towards culture conditioned media confirm this hypothesis. Theoretical and numerical results further suggest an important role for chemotactic-driven aggregation in spreading and survival of tumor cells. |*Chemotaxis/drug effects [MESH] |*Models, Biological [MESH] |Cell Culture Techniques [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Culture Media, Conditioned/pharmacology [MESH]Three-dimensional chemotaxis-driven aggregation of tumor cells (epmc).pdf DeepDyve Pubget Overpricing