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10.1039/c5cc02685g

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C4449287!4449287 !25967743
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suck abstract from ncbi


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pmid25967743
      Chem+Commun+(Camb) 2015 ; 51 (47 ): 9624-7
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  • Thioamides in the collagen triple helix #MMPMID25967743
  • Newberry RW ; VanVeller B ; Raines RT
  • Chem Commun (Camb) 2015[Jun]; 51 (47 ): 9624-7 PMID25967743 show ga
  • To probe noncovalent interactions within the collagen triple helix, backbone amides were replaced with a thioamide isostere. This subtle substitution is the first in the collagen backbone that does not compromise thermostability. A triple helix with a thioamide as a hydrogen bond donor was found to be more stable than triple helices assembled from isomeric thiopeptides.
  • |Circular Dichroism [MESH]
  • |Collagen/*chemistry [MESH]
  • |Entropy [MESH]
  • |Hydrogen Bonding [MESH]
  • |Models, Molecular [MESH]
  • |Protein Structure, Secondary [MESH]


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