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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Pediatr+Rheumatol+Online+J
2016 ; 14
(1
): 26
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Therapeutic advances in the treatment of vasculitis
#MMPMID27112923
Eleftheriou D
; Brogan PA
Pediatr Rheumatol Online J
2016[Apr]; 14
(1
): 26
PMID27112923
show ga
Considerable therapeutic advances for the treatment of vasculitis of the young
have been made in the past 10 years, including the development of outcome
measures that facilitate clinical trial design. Notably, these include: a
recognition that some patients with Kawasaki Disease require corticosteroids as
primary treatment combined with IVIG; implementation of rare disease trial design
for polyarteritis nodosa to deliver the first randomised controlled trial for
children; first clinical trials involving children for anti-neutrophil
cytoplasmic antibody (ANCA) vasculitis; and identification of monogenic forms of
vasculitis that provide an understanding of pathogenesis, thus facilitating more
targeted treatment. Robust randomised controlled trials for Henoch Schönlein
Purpura nephritis and Takayasu arteritis are needed; there is also an
over-arching need for trials examining new agents that facilitate corticosteroid
sparing, of particular importance in the paediatric population since
glucocorticoid toxicity is a major concern.
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