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10.3390/ijms18051036 http://scihub22266oqcxt.onion/10.3390/ijms18051036 C5454948!5454948 !28492519     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28492519 &cmd=llinks): Failed to open stream: HTTP request failed! 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Theranostic Probes for Targeting Tumor Microenvironment: An Overview |pdf=|usr=}}{{28492519 }} gab.com Text Theranostic Probes for Targeting Tumor Microenvironment: An Overview JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28492519 #FOAvip Long gone is the time when tumors were thought to be insular masses of cells, residing independently at specific sites in an organ. Now, researchers gradually realize that tumors interact with the extracellular matrix (ECM), blood vessels, connective tissues, and immune cells in their environment, which is now known as the tumor microenvironment (TME). It has been found that the interactions between tumors and their surrounds promote tumor growth, invasion, and metastasis. The dynamics and diversity of TME cause the tumors to be heterogeneous and thus pose a challenge for cancer diagnosis, drug design, and therapy. As TME is significant in enhancing tumor progression, it is vital to identify the different components in the TME such as tumor vasculature, ECM, stromal cells, and the lymphatic system. This review explores how these significant factors in the TME, supply tumors with the required growth factors and signaling molecules to proliferate, invade, and metastasize. We also examine the development of TME-targeted nanotheranostics over the recent years for cancer therapy, diagnosis, and anticancer drug delivery systems. This review further discusses the limitations and future perspective of nanoparticle based theranostics when used in combination with current imaging modalities like Optical Imaging, Magnetic Resonance Imaging (MRI) and Nuclear Imaging (Positron Emission Tomography (PET) and Single Photon Emission Computer Tomography (SPECT)). Twit Text FOAVip Theranostic Probes for Targeting Tumor Microenvironment: An Overview ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28492519 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28492519 #FOAvip English Wikipedia <ref>{{Cite pmid|28492519 }}</ref> Theranostic Probes for Targeting Tumor Microenvironment: An Overview #MMPMID28492519 Sikkandhar MG ; Nedumaran AM ; Ravichandar R ; Singh S ; Santhakumar I ; Goh ZC ; Mishra S ; Archunan G ; Gulyás B ; Padmanabhan P Int J Mol Sci 2017[May]; 18 (5 ): ä PMID28492519 show ga Long gone is the time when tumors were thought to be insular masses of cells, residing independently at specific sites in an organ. Now, researchers gradually realize that tumors interact with the extracellular matrix (ECM), blood vessels, connective tissues, and immune cells in their environment, which is now known as the tumor microenvironment (TME). It has been found that the interactions between tumors and their surrounds promote tumor growth, invasion, and metastasis. The dynamics and diversity of TME cause the tumors to be heterogeneous and thus pose a challenge for cancer diagnosis, drug design, and therapy. As TME is significant in enhancing tumor progression, it is vital to identify the different components in the TME such as tumor vasculature, ECM, stromal cells, and the lymphatic system. This review explores how these significant factors in the TME, supply tumors with the required growth factors and signaling molecules to proliferate, invade, and metastasize. We also examine the development of TME-targeted nanotheranostics over the recent years for cancer therapy, diagnosis, and anticancer drug delivery systems. This review further discusses the limitations and future perspective of nanoparticle based theranostics when used in combination with current imaging modalities like Optical Imaging, Magnetic Resonance Imaging (MRI) and Nuclear Imaging (Positron Emission Tomography (PET) and Single Photon Emission Computer Tomography (SPECT)). |*Tumor Microenvironment [MESH] |Animals [MESH] |Diagnostic Imaging [MESH] |Disease Models, Animal [MESH] |Drug Delivery Systems [MESH] |Humans [MESH] |Mice [MESH] |Neoplasms/*diagnosis/pathology/*therapy [MESH]Theranostic Probes for Targeting Tumor Microenvironment: An Overview (epmc).pdf DeepDyve Pubget Overpricing