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1989 ; 17
(3
): 257-321
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Theory of oxygen transport to tissue
#MMPMID2673661
Popel AS
Crit Rev Biomed Eng
1989[]; 17
(3
): 257-321
PMID2673661
show ga
This review focuses on the theory of oxygen transport to tissue and presents the
state of the art in mathematical modeling of transport phenomena. Results
obtained with the classic Krogh tissue-cylinder model and recent advances in
mathematical modeling of hemoglobin-oxygen kinetics, the role of hemoglobin and
myoglobin in facilitating oxygen diffusion, and the role of morphologic and
hemodynamic heterogeneities in oxygen transport in the microcirculation are
critically discussed. Mathematical models simulate different parts of the pathway
of oxygen molecules from the red blood cell, through the plasma, the endothelial
cell, other elements of the vascular wall, and the extra- and intracellular
space. Special attention in the review is devoted to intracapillary transport,
which has been the subject of intensive theoretical research in the last decade.
Models of pre- and postcapillary oxygen transport are also discussed.
Applications to specific organs and tissues are reviewed, including skeletal
muscle, myocardium, brain, lungs, arterial wall, and skin. Unresolved problems
and major gaps in our knowledge of the mechanisms of oxygen transport are
identified.
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