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2014 ; 33
(12
): 823-9
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The unexplored roles of human serum IgA
#MMPMID25188736
Leong KW
; Ding JL
DNA Cell Biol
2014[Dec]; 33
(12
): 823-9
PMID25188736
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The roles of human serum IgA, in contrast to that of mucosal IgA, are relatively
unexplored. Previous studies have shown that IgA mediates either pro- or
anti-inflammatory effects in innate immune cells. Serum IgA has been shown to
interact with many proteins and glycoproteins of which the functions and
mechanisms are not fully characterized. Here, we present fresh perspectives into
the roles of serum IgA, describing novel IgA-protein interactions, the importance
of its glycosylation status in normal functions, and the plausible role of IgA as
a driver and regulator of autoimmune diseases/immune overactivation. Other
potential roles, including the regulation of cytokines, effector cell function,
and homeostasis, are considered in view of the maintenance of immune function. We
anticipate future research to uncover new anti-inflammatory or pro-inflammatory
roles of human serum IgA in immune functions and dysfunctions, with implications
on systemic lupus erythematosus (SLE).
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