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10.1093/nar/gkw081 http://scihub22266oqcxt.onion/10.1093/nar/gkw081 C4797306!4797306!26883635     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26883635.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nucleic+Acids+Res 2016 ; 44 (5): 2036-46 Nephropedia Template TP {{tp|p=26883635|t=2016. The structure and intermolecular forces of DNA condensates |pdf=|usr=}}{{26883635}} gab.com Text The structure and intermolecular forces of DNA condensates JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26883635 #FOAvip Spontaneous assembly of DNA molecules into compact structures is ubiquitous in biological systems. Experiment has shown that polycations can turn electrostatic self-repulsion of DNA into attraction, yet the physical mechanism of DNA condensation has remained elusive. Here, we report the results of atomistic molecular dynamics simulations that elucidated the microscopic structure of dense DNA assemblies and the physics of interactions that makes such assemblies possible. Reproducing the setup of the DNA condensation experiments, we measured the internal pressure of DNA arrays as a function of the DNA?DNA distance, showing a quantitative agreement between the results of our simulations and the experimental data. Analysis of the MD trajectories determined the DNA?DNA force in a DNA condensate to be pairwise, the DNA condensation to be driven by electrostatics of polycations and not hydration, and the concentration of bridging cations, not adsorbed cations, to determine the magnitude and the sign of the DNA?DNA force. Finally, our simulations quantitatively characterized the orientational correlations of DNA in DNA arrays as well as diffusive motion of DNA and cations. Twit Text FOAVip The structure and intermolecular forces of DNA condensates ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26883635 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26883635 #FOAvip English Wikipedia <ref>{{Cite pmid|26883635}}</ref> The structure and intermolecular forces of DNA condensates #MMPMID26883635 Yoo J; Aksimentiev A Nucleic Acids Res 2016[Mar]; 44 (5): 2036-46 PMID26883635show ga Spontaneous assembly of DNA molecules into compact structures is ubiquitous in biological systems. Experiment has shown that polycations can turn electrostatic self-repulsion of DNA into attraction, yet the physical mechanism of DNA condensation has remained elusive. Here, we report the results of atomistic molecular dynamics simulations that elucidated the microscopic structure of dense DNA assemblies and the physics of interactions that makes such assemblies possible. Reproducing the setup of the DNA condensation experiments, we measured the internal pressure of DNA arrays as a function of the DNA?DNA distance, showing a quantitative agreement between the results of our simulations and the experimental data. Analysis of the MD trajectories determined the DNA?DNA force in a DNA condensate to be pairwise, the DNA condensation to be driven by electrostatics of polycations and not hydration, and the concentration of bridging cations, not adsorbed cations, to determine the magnitude and the sign of the DNA?DNA force. Finally, our simulations quantitatively characterized the orientational correlations of DNA in DNA arrays as well as diffusive motion of DNA and cations. äThe structure and intermolecular forces of DNA condensates (epmc).pdf DeepDyve Pubget Overpricing