Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28067587
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Transcription
2017 ; 8
(2
): 67-74
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The seven faces of SIRT7
#MMPMID28067587
Blank MF
; Grummt I
Transcription
2017[Mar]; 8
(2
): 67-74
PMID28067587
show ga
SIRT7, a member of the sirtuin family of NAD(+)-dependent protein deacetylases,
is a key mediator of many cellular activities. SIRT7 expression is linked to cell
proliferation and oncogenic activity, connecting SIRT7-dependent regulation of
ribosome biogenesis with checkpoints controlling cell cycle progression,
metabolic homeostasis, stress resistance, aging and tumorigenesis. Despite this
important functional link, the enzymatic activity, the molecular targets and
physiological functions of SIRT7 are poorly defined. Here, we review recent
progress in SIRT7 research and elaborate the main pathways in which SIRT7
participates.