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10.12703/P7-56 http://scihub22266oqcxt.onion/10.12703/P7-56 C4447049!4447049 !26097729     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26097729 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26097729 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       F1000Prime+Rep 2015 ; 7 (ä): 56 Nephropedia Template TP {{tp|p=26097729 |t=2015. The search for novel analgesics: targets and mechanisms |pdf=|usr=}}{{26097729 }} gab.com Text The search for novel analgesics: targets and mechanisms JO: F1000Prime Rep http://www.kidney.de/pget.php?&tw=1&pmid=26097729 #FOAvip The management of the pain state is of great therapeutic relevance to virtually every medical specialty. Failure to manage its expression has deleterious consequence to the well-being of the organism. An understanding of the complex biology of the mechanisms underlying the processing of nociceptive information provides an important pathway towards development of novel and robust therapeutics. Importantly, preclinical models have been of considerable use in determining the linkage between mechanism and the associated behaviorally defined pain state. This review seeks to provide an overview of current thinking targeting pain biology, the use of preclinical models and the development of novel pain therapeutics. Issues pertinent to the strengths and weaknesses of current development strategies for analgesics are considered. Twit Text FOAVip The search for novel analgesics: targets and mechanisms ????F1000Prime Rep http://www.kidney.de/pget.php?&tw=1&pmid=26097729 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26097729 #FOAvip English Wikipedia <ref>{{Cite pmid|26097729 }}</ref> The search for novel analgesics: targets and mechanisms #MMPMID26097729 Yaksh TL ; Woller SA ; Ramachandran R ; Sorkin LS F1000Prime Rep 2015[]; 7 (ä): 56 PMID26097729 show ga The management of the pain state is of great therapeutic relevance to virtually every medical specialty. Failure to manage its expression has deleterious consequence to the well-being of the organism. An understanding of the complex biology of the mechanisms underlying the processing of nociceptive information provides an important pathway towards development of novel and robust therapeutics. Importantly, preclinical models have been of considerable use in determining the linkage between mechanism and the associated behaviorally defined pain state. This review seeks to provide an overview of current thinking targeting pain biology, the use of preclinical models and the development of novel pain therapeutics. Issues pertinent to the strengths and weaknesses of current development strategies for analgesics are considered. äThe search for novel analgesics: targets and mechanisms (epmc).pdf DeepDyve Pubget Overpricing