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2015 ; 35
(1
): 198-223
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The roles of cellular nanomechanics in cancer
#MMPMID25137233
Yallapu MM
; Katti KS
; Katti DR
; Mishra SR
; Khan S
; Jaggi M
; Chauhan SC
Med Res Rev
2015[Jan]; 35
(1
): 198-223
PMID25137233
show ga
The biomechanical properties of cells and tissues may be instrumental in
increasing our understanding of cellular behavior and cellular manifestations of
diseases such as cancer. Nanomechanical properties can offer clinical translation
of therapies beyond what are currently employed. Nanomechanical properties, often
measured by nanoindentation methods using atomic force microscopy, may identify
morphological variations, cellular binding forces, and surface adhesion behaviors
that efficiently differentiate normal cells and cancer cells. The aim of this
review is to examine current research involving the general use of atomic force
microscopy/nanoindentation in measuring cellular nanomechanics; various factors
and instrumental conditions that influence the nanomechanical properties of
cells; and implementation of nanoindentation methods to distinguish cancer cells
from normal cells or tissues. Applying these fundamental nanomechanical
properties to current discoveries in clinical treatment may result in greater
efficiency in diagnosis, treatment, and prevention of cancer, which ultimately
can change the lives of patients.
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