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2015 ; 8
(5
): 5089-96
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The roles of APOBEC3B in gastric cancer
#MMPMID26191203
Zhang J
; Wei W
; Jin HC
; Ying RC
; Zhu AK
; Zhang FJ
Int J Clin Exp Pathol
2015[]; 8
(5
): 5089-96
PMID26191203
show ga
Gastric cancer was the third cause of death in China. In this study, we found
that the APOBEC3 (apolipoprotein B mRNA-editing enzyme, catalytic
polypeptide-like 3) expression was higher in gastric cancer tissues than that in
normal tissues and confirmed APOBEC3B expression was correlated with the
unfavorable prognosis of the patients with gastric cancer. Furthermore, APOBEC3B
expression was associated with gender, tumor size, histological grade, T stage,
and TNM staging of the patients with gastric cancer. Down-regulation of APOBEC3B
expression in MNK28 cells could enhance the cytotoxicity of PDCD2. No editing
took place in PDCD2 positive MKN28 cells with APOBEC3B shRNA. These results
indicated that loss of function of PDCD2 may be partly caused by APOBEC3B-induced
extensive mutagenesis.
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