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10.18632/oncotarget.13907 http://scihub22266oqcxt.onion/10.18632/oncotarget.13907 C5354804!5354804 !27965469     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27965469 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Oncotarget 2017 ; 8 (3 ): 3933-3945 Nephropedia Template TP {{tp|p=27965469 |t=2017. The role of tumor microenvironment in therapeutic resistance |pdf=|usr=}}{{27965469 }} gab.com Text The role of tumor microenvironment in therapeutic resistance JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27965469 #FOAvip Cancer cells undergo unlimited progression and survival owing to activation of oncogenes. However, support of the tumor microenvironment is essential to the formation of clinically relevant tumors. Recent evidence indicates that the tumor microenvironment is a critical regulator of immune escape, progression, and distant metastasis of cancer. Moreover, the tumor microenvironment is known to be involved in acquired resistance of tumors to various therapies. Despite significant advances in chemotherapy and radiotherapy, occurrence of therapeutic resistance leads to reduced efficacy. This review highlights myeloid cells, cancer-associated fibroblasts, and mesenchymal stem cells consisting of the tumor microenvironment, as well as the relevant signaling pathways that eventually render cancer cells to be therapeutically resistant. Twit Text FOAVip The role of tumor microenvironment in therapeutic resistance ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27965469 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27965469 #FOAvip English Wikipedia <ref>{{Cite pmid|27965469 }}</ref> The role of tumor microenvironment in therapeutic resistance #MMPMID27965469 Son B ; Lee S ; Youn H ; Kim E ; Kim W ; Youn B Oncotarget 2017[Jan]; 8 (3 ): 3933-3945 PMID27965469 show ga Cancer cells undergo unlimited progression and survival owing to activation of oncogenes. However, support of the tumor microenvironment is essential to the formation of clinically relevant tumors. Recent evidence indicates that the tumor microenvironment is a critical regulator of immune escape, progression, and distant metastasis of cancer. Moreover, the tumor microenvironment is known to be involved in acquired resistance of tumors to various therapies. Despite significant advances in chemotherapy and radiotherapy, occurrence of therapeutic resistance leads to reduced efficacy. This review highlights myeloid cells, cancer-associated fibroblasts, and mesenchymal stem cells consisting of the tumor microenvironment, as well as the relevant signaling pathways that eventually render cancer cells to be therapeutically resistant. |*Drug Resistance, Neoplasm [MESH] |*Radiation Tolerance [MESH] |Epithelial-Mesenchymal Transition [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Mesenchymal Stem Cells/cytology/metabolism [MESH] |Myeloid Cells/cytology/metabolism [MESH] |Neoplasms/*metabolism [MESH]The role of tumor microenvironment in therapeutic resistance (epmc).pdf DeepDyve Pubget Overpricing