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2014 ; 33
(6
): 498-510
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The role of the liver in sepsis
#MMPMID24611785
Yan J
; Li S
; Li S
Int Rev Immunol
2014[Nov]; 33
(6
): 498-510
PMID24611785
show ga
Despite the progress made in the clinical management of sepsis, sepsis morbidity
and mortality rates remain high. The inflammatory pathogenesis and organ injury
leading to death from sepsis are not fully understood for vital organs,
especially the liver. Only recently has the role of the liver in sepsis begun to
be revealed. Pre-existing liver dysfunction is a risk factor for the progression
of infection to sepsis. Liver dysfunction after sepsis is an independent risk
factor for multiple organ dysfunction and sepsis-induced death. The liver works
as a lymphoid organ in response to sepsis. Acting as a double-edged sword in
sepsis, the liver-mediated immune response is responsible for clearing bacteria
and toxins but also causes inflammation, immunosuppression, and organ damage.
Attenuating liver injury and restoring liver function lowers morbidity and
mortality rates in patients with sepsis. This review summarizes the central role
of liver in the host immune response to sepsis and in clinical outcomes.
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