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10.1172/JCI90962 http://scihub22266oqcxt.onion/10.1172/JCI90962 C5330758!5330758 !28248200     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28248200 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28248200 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Clin+Invest 2017 ; 127 (3 ): 780-789 Nephropedia Template TP {{tp|p=28248200 |t=2017. The role of the complement system in cancer |pdf=|usr=}}{{28248200 }} gab.com Text The role of the complement system in cancer JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=28248200 #FOAvip In addition to being a component of innate immunity and an ancient defense mechanism against invading pathogens, complement activation also participates in the adaptive immune response, inflammation, hemostasis, embryogenesis, and organ repair and development. Activation of the complement system via classical, lectin, or alternative pathways generates anaphylatoxins (C3a and C5a) and membrane attack complex (C5b-9) and opsonizes targeted cells. Complement activation end products and their receptors mediate cell-cell interactions that regulate several biological functions in the extravascular tissue. Signaling of anaphylatoxin receptors or assembly of membrane attack complex promotes cell dedifferentiation, proliferation, and migration in addition to reducing apoptosis. As a result, complement activation in the tumor microenvironment enhances tumor growth and increases metastasis. In this Review, I discuss immune and nonimmune functions of complement proteins and the tumor-promoting effect of complement activation. Twit Text FOAVip The role of the complement system in cancer ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=28248200 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28248200 #FOAvip English Wikipedia <ref>{{Cite pmid|28248200 }}</ref> The role of the complement system in cancer #MMPMID28248200 Afshar-Kharghan V J Clin Invest 2017[Mar]; 127 (3 ): 780-789 PMID28248200 show ga In addition to being a component of innate immunity and an ancient defense mechanism against invading pathogens, complement activation also participates in the adaptive immune response, inflammation, hemostasis, embryogenesis, and organ repair and development. Activation of the complement system via classical, lectin, or alternative pathways generates anaphylatoxins (C3a and C5a) and membrane attack complex (C5b-9) and opsonizes targeted cells. Complement activation end products and their receptors mediate cell-cell interactions that regulate several biological functions in the extravascular tissue. Signaling of anaphylatoxin receptors or assembly of membrane attack complex promotes cell dedifferentiation, proliferation, and migration in addition to reducing apoptosis. As a result, complement activation in the tumor microenvironment enhances tumor growth and increases metastasis. In this Review, I discuss immune and nonimmune functions of complement proteins and the tumor-promoting effect of complement activation. |Animals [MESH] |Apoptosis/immunology [MESH] |Cell Communication/*immunology [MESH] |Cell Proliferation [MESH] |Complement Pathway, Alternative/*immunology [MESH] |Complement Pathway, Classical/*immunology [MESH] |Complement System Proteins/*immunology [MESH] |Humans [MESH] |Neoplasms/*immunology [MESH]The role of the complement system in cancer (epmc).pdf DeepDyve Pubget Overpricing