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10.1111/jcmm.12590 http://scihub22266oqcxt.onion/10.1111/jcmm.12590 C4511346!4511346 !26081217     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26081217 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Mol+Med 2015 ; 19 (7 ): 1471-82 Nephropedia Template TP {{tp|p=26081217 |t=2015. The role of tanycytes in hypothalamic glucosensing |pdf=|usr=}}{{26081217 }} gab.com Text The role of tanycytes in hypothalamic glucosensing JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26081217 #FOAvip Tanycytes are elongated hypothalamic glial cells that cover the basal walls of the third ventricle; their apical regions contact the cerebrospinal fluid (CSF), and their processes reach hypothalamic neuronal nuclei that control the energy status of an organism. These nuclei maintain the balance between energy expenditure and intake, integrating several peripheral signals and triggering cellular responses that modify the feeding behaviour and peripheral glucose homeostasis. One of the most important and well-studied signals that control this process is glucose; however, the mechanism by which this molecule is sensed remains unknown. We along with others have proposed that tanycytes play a key role in this process, transducing changes in CSF glucose concentration to the neurons that control energy status. Recent studies have demonstrated the expression and function of monocarboxylate transporters and canonical pancreatic ? cell glucose sensing molecules, including glucose transporter 2 and glucokinase, in tanycytes. These and other data, which will be discussed in this review, suggest that hypothalamic glucosensing is mediated through a metabolic interaction between tanycytes and neurons through lactate. This article will summarize the recent evidence that supports the importance of tanycytes in hypothalamic glucosensing, and discuss the possible mechanisms involved in this process. Finally, it is important to highlight that a detailed analysis of this mechanism could represent an opportunity to understand the evolution of associated pathologies, including diabetes and obesity, and identify new candidates for therapeutic intervention. Twit Text FOAVip The role of tanycytes in hypothalamic glucosensing ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26081217 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26081217 #FOAvip English Wikipedia <ref>{{Cite pmid|26081217 }}</ref> The role of tanycytes in hypothalamic glucosensing #MMPMID26081217 Elizondo-Vega R ; Cortes-Campos C ; Barahona MJ ; Oyarce KA ; Carril CA ; García-Robles MA J Cell Mol Med 2015[Jul]; 19 (7 ): 1471-82 PMID26081217 show ga Tanycytes are elongated hypothalamic glial cells that cover the basal walls of the third ventricle; their apical regions contact the cerebrospinal fluid (CSF), and their processes reach hypothalamic neuronal nuclei that control the energy status of an organism. These nuclei maintain the balance between energy expenditure and intake, integrating several peripheral signals and triggering cellular responses that modify the feeding behaviour and peripheral glucose homeostasis. One of the most important and well-studied signals that control this process is glucose; however, the mechanism by which this molecule is sensed remains unknown. We along with others have proposed that tanycytes play a key role in this process, transducing changes in CSF glucose concentration to the neurons that control energy status. Recent studies have demonstrated the expression and function of monocarboxylate transporters and canonical pancreatic ? cell glucose sensing molecules, including glucose transporter 2 and glucokinase, in tanycytes. These and other data, which will be discussed in this review, suggest that hypothalamic glucosensing is mediated through a metabolic interaction between tanycytes and neurons through lactate. This article will summarize the recent evidence that supports the importance of tanycytes in hypothalamic glucosensing, and discuss the possible mechanisms involved in this process. Finally, it is important to highlight that a detailed analysis of this mechanism could represent an opportunity to understand the evolution of associated pathologies, including diabetes and obesity, and identify new candidates for therapeutic intervention. |Animals [MESH] |Cell Communication [MESH] |Ependymoglial Cells/*metabolism [MESH] |Glucokinase/metabolism [MESH] |Glucose Transport Proteins, Facilitative/metabolism [MESH] |Glucose/*metabolism [MESH] |Humans [MESH]The role of tanycytes in hypothalamic glucosensing (epmc).pdf DeepDyve Pubget Overpricing